© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Lockdown measures in response to the COVID-19 pandemic involve placing huge burdens on some members of society for the sake of benefiting other members of society. How should we decide when these policies are permissible? Many writers propose we should address this question using cost-benefit analysis, a broadly consequentialist approach. We argue for an alternative non-consequentialist approach, grounded in contractualist moral theorising. The first section sets up key issues in the ethics of lockdown, and sketches the apparent appeal of addressing (...) these problems in a CBA frame. The second section argues that CBA fundamentally distorts the normative landscape in two ways: first, in principle, it allows very many morally trivial preferences—say, for a coffee—might outweigh morally weighty life-and-death concerns; second, it is insensitive to the core moral distinction between victims and vectors of disease. The third section sketches our non-consequentialist alternative, grounded in Thomas Scanlon’s contractualist moral theory. On this account, the ethics of self-defence implies a strong default presumption in favour of a highly restrictive, universal lockdown policy: we then ask whether there are alternatives to such a policy which are justifiable to all affected parties, paying particular attention to the complaints of those most burdened by policy. In the fourth section, we defend our contractualist approach against the charge that it is impractical or counterintuitive, noting that actual CBAs face similar, or worse, challenges. (shrink)

This paper explores some of the ethical issues around offering COVID-19 vaccines to children. My main conclusion is rather paradoxical: the younger we go, the stronger the grounds for justified parental hesitancy and, as such, the stronger the arguments for enforcing vaccination. I suggest that this is not thereductio ad absurdumit appears, but does point to difficult questions about the nature of parental authority in vaccination cases. The first section sketches the disagreement over vaccinating teenagers, arguing that the UK policy (...) was permissible. The second section outlines a problem for this policy, that it faces justified vaccine hesitancy. The third section discusses three strategies for responding to this problem, arguing that there may be no simple way of overcoming parents’ reasons to resist vaccinations. (shrink)

“This is my major thesis. Mystery is inherent in both the nature of things and the nature of rationality. I will sustain this thesis by a review of some of the central issues of philosophy to elucidate their mysterious qualities. More important, however, I will develop in detail an explanation of mystery and trace some of its important ramifications.” “I will argue that an ordinal metaphysics, with its associated theory of query, provides an account of mystery that no other theory (...) can provide. “While the theory presented here is a theory of philosophical mystery, it has fundamental implications for all branches of knowledge, including the physical and social sciences. “In short, I speak against a simplistic view of the world and of experience based on a simplistic and narrow conception of understanding and rationality. Mystery calls not for veneration and awe, but for a full and complex activity of mind, broaching all established conditions in its pursuit of answers....Reason is fulfilled as completely in mysteries which persevere throughout our efforts to resolve them as in mysteries which are resolved and dissipated, passing into new questions to which we must find new answers, in an unterminating process of rational interrogation.” — From the Preface by Stephen David Ross. (shrink)

Explores how we might think and live in the enchantment of the secular, modern world.

This work completes Ross 's trilogy examining the inexhaustible complexity of the world and our relation to our surroundings.

Some preliminary observations must be made concerning the nature and purpose of this study. What I have attempted here is an essay in the metaphysics of science, and not the "philosophy of science. " Rather than concentrating on the details of theory-construction and the for mal structure of scientific systems, I have treated science as an enter prise, a developing process within human experience. I have used such an approach in order to analyze science in its relationship to other human (...) enterprises, such as art and philosophy, and to clarify its unique goals and characteristics. Often the concepts employed in descriptions of scientific methods are conceived too narrowly; by broadening the focus of attention I have attempted to characterize in a fairly general fashion the goals and methods of science. This has led to formulations which may seem at first glance to depart radically from some "well established" distinctions of the philosophy of science. I hope that it will be clear, however, that such formulations arise at a different level of analysis and concern very different problems from those of the logic of science. In particular, I am concerned with the general goals of science. These must not be confused with the narrower principles of method employed in science at any given time. (shrink)

Traces the history of the idea of art as an ethical movement, interpreting the good as nature's abundance, giving rise to an ethics of inclusion, expressed in art.

Ross (philosophy and comparative literature, State U. of New York, Binghamton) explores how it might be possible to represent representation. Interpretations of a wide range of modern philosophical works combine with original contributions.

Sometimes, states face emergencies: situations where many individuals face an imminent threat of serious harm. Some believe that in such cases certain sorts of actions which are normally morally prohibited might be permissible. In this paper, I discuss this view as it applies in both the contexts of war and of public health policy. I suggest that the deontologist can best understand emergencies by analogy with the distinction between act- and rule consequentialism. In real world cases, we must often make (...) decisions in ‘epistemically murky’ situations, such that the application of deontological principles to particular cases is unclear. I suggest that we develop conventions to deal with such cases in a manner which we think is most likely to approximate the demands of abstract deontological principles across time. I claim that we can best understand ‘supreme emergencies’ as situations which ‘epistemic murkiness’ is resolved. In such cases, there may be a conflict between what would be valid application of abstract deontological principles and the conventions which normally guide us in epistemically murky situations. (shrink)

IF MODERN philosophy began with Cartesian doubt, it threatens to end not with a resolution of skepticism but with its dissipation. The skeptic's demand for total justification has been replaced by a repudiation of foundations. Such repudiation has been formulated in terms of holism, contextualism, pragmatism, and interpretationism. Yet some of these approaches display significant difficulties even if we accept their denial of foundations. The approach I will examine in particular here is Richard Rorty's version of holism. I will criticize (...) it not for its denial of foundations--with which I am in complete agreement--but for its incompleteness. I will argue that if we take Rorty's anti-foundationalism seriously, we must develop his theory in certain directions much further than he takes it himself. The directions to be pursued in such developments will become clearer in the course of the discussion. I am particularly concerned to explore the possibility of a systematic but anti-foundational theory--one similar in certain ways to but fundamentally incompatible with holism. I will argue that a metaphysical theory can be developed which accommodates the force of Rorty's, Heidegger's, and Dewey's contextualism--a theory which might be called a perspectival realism. (shrink)

Physical pain has no voice, but when it at last finds a voice, it begins to tell a story, and the story that it tells is about the inseparability of these three subjects, their embeddedness in one another. (Scarry, BP, 3).

Introduction: The forgotten -- Re-calling -- Re-membering -- Unremembering -- Enlightenment -- History -- Counter-memory -- Body and image -- Past and future -- Everyday life -- Diachrony -- Inheritance -- Pain -- Disaster.

The word person is Latin: . . . which signifies the face, as persona in Latin signifies the disguise, or outward appearance of a man, counterfeited on the stage; and sometimes more particularly that part of it, which disguiseth the face, as a mask or vizard:. . . . So that a person, is the same that an actor is, both on the stage and in common conversation; and to personate, is to act, or represent himself, or another;. . . (...) . (Hobbes, L, 1, 16, p. 147)Whatever is profound loves masks; what is most profound even hates image and parable. Might not nothing less than the opposite be the proper disguise for the shame of a god? . . .Every profound spirit needs a mask: even more, around every profound spirit a mask is growing continually, owing to the constantly false, namely shallow, interpretation of every word, every step, every sign of life he gives. (Nietzsche, BGE, #40)we are difference, . . . our history the difference of times, our selves the difference of masks.1 (Foucault, AK, 131)The image, at first sight, does not resemble the cadaver, but it is possible that the rotting, decaying, cadaverous strangeness might also be from the image.2 (Blanchot, TVI, 256)the eternal return is said only of the theatrical world of the metamorphosesand masks of the Will to power,. . . . (Deleuze, DR, 40–1). (shrink)

This book addresses the nature and injustice of authority, retracing the ideas of reason and law from ancient Greece to the present, pursuing a line of thought begun with Anaximander, who speaks of the ordinance of time as restitution for ...

Like many, I find the idea of relying on patient preference predictors in life-or-death cases ethically troubling. As part of his stimulating discussion, Sharadin1 diagnoses such unease as a worry that using PPPs disrespects patients’ autonomy, by treating their most intimate and significant desires as if they were caused by their demographic traits. I agree entirely with Sharadin’s ‘debunking’ response to this concern: we can use statistical correlations to predict others’ preferences without thereby assuming any causal claim. However, I suspect (...) that, for at least some of us, our unease about PPPs stems from a different kind of ‘autonomy’ concern. In this commentary, then, I will explore this concern, and show how it relates to Sharadin’s work. Very many of our preferences are caused, ultimately, by facts which are outside our control, such as our demographic features. However, I suggest that we can still act autonomously on the basis of such preferences, when they are preferences which we endorse. Imagine, for example, that Jane has grown up in a church-growing environment, which has shaped many of her preferences, …. (shrink)

A giving which gives only its gift, but in the giving holds itself back and withdraws, . . . . (Heidegger, TB, 8)the Forgotten is . . . the Law. (Lyotard, “HJ," 147)how could this thought (Heidegger’s), a thought so devoted to remembering that a forgetting (of Being) takes place in all thought, in all art, in all “representation” of the world, how could it possibly have ignored the thought of [that] which, in a certain sense, thinks, tries to think, (...) nothing but that very fact? . . . to the point of suppressing and foreclosing to the very end the horrifying (and inane) attempt at exterminating, at making us forget forever what, in Europe, reminds us, ever since the beginning, that “there is” the Forgotten? (Lyotard, HJ, 4)[I]n witnessing, one also exterminates. The witness is a traitor. (Lyotard, I, 204)The Other becomes my neighbour precisely through the way the face summons me, calls for me, begs for me, and in so doing recalls my responsibility, and calls me into question.. . . as if I had to answer for the other’s death even before being. (83). (shrink)

Without the mind of a seer, I now maintain that I can predict (vorhersagen) from the aspects and precursor—signs (Vorzeichen) of our times, the achievement (Erreichung) of this end, and with it, at the same time, the progressive improvement of mankind, a progress which henceforth cannot be totally reversible . . . a phenomenon of this kind in human history can never be forgotten (vergisst sich nicht mehr). (Kant, CF; quoted in Lyotard, SH, 408).

[T]he common character of the mildest, as well as the severest cases, to which the faulty and chance actions contribute, lies in the ability to refer the phenomena to unwelcome, repressed, psychic material, which, though pushed away from consciousness, is nevertheless not robbed of all capacity to express itself. (Freud, PEL, 146).

Zen-Buddhist nothingness is the nowhere is there something that is I, or conversely: the I that is the nowhere is there something. (Hisamatsu, FN, 25-26; quoted and trans. in Stambaugh, FS, 76)... it is empty of being. That means that it is beyond all measure ....... it is empty without emptiness. That means that it does not cling to itself.... it possesses nothing. That means that it doesn't possess and also cannot be possessed. (Hisamatsu, FN, 31; quoted and trans. in (...) Stambaugh, FS, 77-8)The emptiness of what is called "emptiness" is referred to as "the emptiness of emptiness" (ʼsūnyatāʼsūnyatā), and it is explained in this way for the purpose of controverting any understanding of emptiness as a[n ontological reference to] "being." (Candrakīrti, EMW, 180)A skillful Zen student will strive to be awakened to an identity with all phenomena, the student him- or herself emptyand continually changing as the phenomena come forth. (Codiga, ZPSP, 108)Zen practice is a means for the enlightenment of bushes and grasses, an activity that has no beginning or end in the vastness of any empty universe. (p. 110). (shrink)

By submitting to the primacy of the question “What?” the phenomenology of memory finds itself at the outset confronting a formidable aporia present in ordinary language: the presence in which the representation of the past seems to consist does indeed appear to be that of an image. We say interchangeably that we represent a past event to ourselves or that we have an image of it, an image that can be either quasi visual or auditory. . . . Memory, reduced (...) to recall, thus operates in the wake of the imagination. . . .As a countercurrent to this tradition of devaluing memory, in the margins of a critique of imagination, there has to be an uncoupling of imagination from memory as far as this operation can be extended. (Ricoeur, MHF, 5–6). (shrink)

Memory is, therefore, neither perception nor conception, but a state or affection of one of these, conditioned by lapse of time. As already observed, there is no such thing as memory of the present while present; for the present is object only of perception, and the future, of expectation, but the object of memory is the past. All memory, therefore, implies a time elapsed; consequently only those animals which perceive time remember, and the organ whereby they perceive time is also (...) that whereby they remember. (Aristotle, OM, 449b24–30). (shrink)

Man, in the analytic of finitude, is a strange empirico-transcendental doublet, since he is a being such that knowledge will be attained in him of what renders all knowledge possible. (Foucault, OT, 318)Man is a mode of being which accommodates that dimension-always open, never finally delimited, yet constantly traversed-which extends from a part of himself not reflected in a cogito to the act of thought by which he apprehends that part; and which, in the inverse direction, extends from that pure (...) apprehension to ... the whole silent horizon of what is posited in the sandy stretches of non-thought .... The question is no longer: How can experience of nature give rise to necessary judgements? But rather: How can man think what he does not think, inhabit as though by a mute occupation something that eludes him, animate with a kind of frozen movement that figure of himself that takes the form of a stubborn exteriority? (pp. 322-3). (shrink)

At the centre of the principle, always, the One does violence to itself, and guards itself against the other. (Derrida, PF, ix)The One betrays itself in betraying the other.The self double crosses itself in double crossing the others.

The image, at first sight, does not resemble the cadaver, but it is possible that the rotting, decaying, cadaverous strangeness might also be from the image. (Blanchot, EL, 344; [my translation])But what is the image? When there is nothing, the image finds in this nothing its necessary condition, but there it disappears. The image needs the neutrality and the fading of the world: it wants everything to return to the indifferent deep where nothing is affirmed; it tends toward the intimacy (...) of what still subsists in the void. This is its truth. But this truth exceeds it. (Blanchot, SL, 254). (shrink)

The ownership condemned with such rigor by the mystics, and often called impurity, is only the search for one's own solace and one's own interest in the jouissance of the gifts of God, at the expense of the jealousy of the pure love that wants everything for God and nothing for the creature .... Ownership, of course, is nothing but self-love or pride, which is the love of one's own excellence insofar as it is one's own, and which, instead of (...) coming back completely and uniquely to God, still to a small extent brings the gifts of God back to the self so that it can takepleasure in them. (Fénelon: quoted in Nancy, SL, 94)Love defines itself as the absolute opposite and as the destruction of self-love. Self-love is not simply the love of the self; .... One can love oneself with a real love, and it might even be that one must do so .... But self-love, understood according to the signification the spiritual authors gave to it, .... is the love (which, from this moment on, is no longer one) of possession. It is the love of the self as property. (pp. 94-5). (shrink)

Dasein is authentically itself only to the extent that, as concernful Being-alongside and solicitous Being-with, it projects itself upon its ownmost potentiality-for-Being rather than upon the possibility of the they-self. (Heidegger, BT, 308)The more I return to myself, the more I divest myself, under the traumatic effect of persecution, of my freedom as a constituted, willful, imperialist subject, the more I discover myself to be responsible; the more just I am, the more guilty I am. I am "in myself" through (...) the others. (Levinas, OB, 112)these singular beings [Daseins] are themselves constituted by sharing, they are distributed and placed, or rather spaced, by the sharing that makes them others: other for one another, and other, infinitely other for the Subject of their fusion, which is engulfed in the sharing, in the ecstasy of the sharing "communicating" by not "communing." ... Thus, the communication of sharing would be this very dis-location. (Nancy, IC, 25)What defines the "self" is precisely what defines us as personsnamely, the various roles and relationships that link us to others. (Bockover, ERS, 56). (shrink)

Explores the human propensity for owning and having.

wonder is the feeling of a philosopher, and philosophy begins in wonder. He was not a bad genealogist who said that Iris [the messenger of heaven] is the child of Thaumas [wonder].1 (Plato,Theaetetus, 155d)When our first encounter with some object surprises us and we find it novel, or very different from what we formerly knew or from what we supposed it ought to be, this causes us to wonder and to be astonished at it. . . . I regard wonder (...) as the first of all the passions. (Descartes, PS, 350)Wonder . . . is the passion of that which is already born and not yet reenveloped in love. . . . It is the passion of the first encounter. And of perpetual rebirth? . . . the place of incidence and junction of body and spirit, which has been covered over again and again, hardened through repetitions that hamper growth and flourishing (croissance et épanouissement [unfolding, blossoming])? . . . A third dimension. An intermediary. Neither the one nor the other. Which is not to say neutral or neuter. The forgotten ground of our condition between mortal and immortal, men andgods, creatures and creators. In us and among us. (Irigaray, ESD, 81–2). (shrink)

According to my entire understanding here, art is itself an emanation of the absolute. The history of art will show us most revealingly its immediate connections to the conditions of the universe and thereby to that absolute identity in which art is preordained. Only in the history of art does the essential and inner unity of all works of art reveal itself, a unity showing that all poetry is of the same spirit, a spirit that even in the antitheses of (...) ancient and modern art is merely showing its two different faces. §14. The indifference of the ideal and the real as indifference manifests itself in the ideal world through art, for art is in itself neither mere activity nor mere knowledge, but is rather an activity completely permeated by knowledge, or in a reverse fashion knowledge that has completely become activity. That is, it is the indifference of both. (shrink)

Strong social identity does not lead to lack of accountability and “bad” behavior in groups and crowds but rather causes group behavior to be driven by group norms. The solution to problematic group behavior is therefore not to individualize the group but rather to change group norms, as underlined by the relational dynamics widely studied in the SIDE tradition.

Sixth volume devoted to the good. Human, natural worlds filled with gifts. Nature, general economy of the good, earth's abundance, beyond measure. Gifts and giving, beyond having. Cherishment, sacrifice, plenishment: exposure to the good. Plato. The good grants authority to knowledge and truth. Anaximander. Injustice, restitution.Beauty, truth, justice gifts from the good. Precedence in Western philosophic tradition to gathering, assembling, and having being. Love of self as having. A self beyond itself, giving beyond having. Ethic responsive to the heterogeneous abundance (...) of things in the earth. (shrink)

I wish to take up the subject ... in relation to a set of practices in late antiquity. Among the Greeks, these practices took the form of a precept: epimeleisthai sautou, "to take care of yourself," to take "care of the self," "to be concerned, to take care of yourself."The precept of the "care of the self" [souci de soi] was, for the Greeks, one of the main principles of cities, one of the main rules for social and personal conduct (...) and for the art of life. For us now, this notion is rather obscure and faded. (Foucault, TS, 19). (shrink)

Into those things from which existing things have their coming into being, their passing away, too, takes place, according to what must be; for they make reparation to one another for their injustice according to the ordinance of time . . . . (Anaximander fragment; Simplicius Phys., 24, 18 [DK 12 B 1]; trans. Robinson, EGP, 34)[T]o remember and to bear witness to something that is constitutively forgotten, not only in each individual mind, but in the very thought of the (...) West. (Lyotard, “HJ,” 141)To bear witness to the differend. (Lyotard, DPD, xiii)[I]n witnessing, one also exterminates. (I, 204)Reality is composed of the différend. (shrink)

Quantum aesthetics fosters what might be called a general thesis of metaphysical intimacy. There is no place left, even in nature, where uninterpreted events can hide. With regard to the work of Niels Bohr and Heisenberg, this condition of unavoidable interpretation is referred to as the “indivisibility of the quantum action.” Accordingly, talking about any privileged or pristine considerations involves contradictions that, according to advocates of quantum aesthetics, must be overcome. Now, every facet of existence has a voice that has (...) a human origin and must be correctly deciphered. Even nature is not simply confronted, but must be explored in terms of its cultural nuances. (Caro and Murphy, eds., WQC, 182). (shrink)

Possession is preeminently the form in which the other becomes the same, by becoming mine. (Levinas, TI, 46)If perceptions are distinct existences, they form a whole only by being connected together. But no connexions among distinct existences are ever discoverable by human understanding. We only feel a connexion or determination of the thought to pass from one object to another. It follows, therefore, that the thought alone feels personal identity, when reflecting on the train of past perceptions that compose a (...) mind, the ideas of them are felt to be connected together, and naturally introduce each other. (Burne, T, App., 635)The I think must accompany all my representations, for otherwise something would be represented in me which could not be thought: .... they must conform to the condition under which alone they can exist altogether in a common self-consciousness, because otherwise they would not all without exception belong to me. (Kant, CPR, 76-7). (shrink)

Este artículo discute la cercana relación entre la teología y la filosofía natural de Newton. Tomando como punto de inscripción el ejemplo de la Óptica, se refutarán estas lecturas de Newton. Primero, se examinará la evidencia que muestra que Newton contempló una declaración explícita de filosofía natural para la primera edición de la Óptica. Luego se discutirá el material teológico-natural añadido a la Optice de 1706. Al hacerlo, se señalarán ejemplos de su relación con las afirmaciones hechas en el Escolio (...) General de los Principia, se demostrará cómo éste está iluminado por las afirmaciones más explícitas hechas en un borrador a la Cuestión 23 (31), y se explorarán conexiones entre las declaraciones públicas de las Cuestiones y material más explícito sobre teología natural en los manuscritos privados de Newton. Luego se mostrará que, así como en el Escolio General, el material añadido a las ediciones posteriores de la Óptica también incluye claves sobre su teología antitrinitaria herética. Finalmente, se sugerirán formas en que los compromisos de Newton con la teología natural, y un poderoso Dios unitario del dominio, ayudaron a sustentar su filosofía natural. En suma, este artículo sostiene que la teología natural de Newton y su teología herética se relacionan con la filosofía natural de la Óptica de maneras que son mucho más fundamentales que un delgado barniz de retórica. Este artículo se basa no sólo en un análisis de los textos publicados, sino también de los borradores relacionados con la Óptica y otros paralelos textuales en los escritos inéditos de Newton. Estos manuscritos privados ayudarán a abrir una ventana en el sentido que buscaban los textos públicos de Newton. (shrink)